WebNov 15, 2024 · The E2F-DP transcription factor family, widely distributed in variety of organisms, plays an important role in cell cycle regulation. In recent years, great … WebAug 28, 2006 · Each of the E2F polypeptides can heterodimerize with either DP1 or DP2 (DP3) (Ormondroyd et al., 1995), although the E2F7 transcription factor binds DNA in a DP-independent manner.
The Rb/E2F pathway and cancer - OUP Academic
WebMay 6, 2008 · Characterization of the E2F consensus motifs that are not bound by E2F1. Our previous studies (Bieda et al. 2006; Xu et al. 2007), indicating that only 4%–10% of the identified in vivo E2F binding sites contain a consensus E2F motif, had focused on a relatively small set (∼100–200) of E2F binding sites found using genomic tiling arrays … how much is my mobile phone worth
Negative regulator of E2F transcription factors links cell cycle ... - PNAS
WebA. Introduction. E2F-1 belongs to the E2F family of transcription factors that regulate the expression of genes involved in cell-cycle progression, especially at the G1 to S phase … WebAug 7, 2014 · The E2F proteins comprise a family of 8 members that function as transcription factors. They are key targets of the retinoblastoma protein (RB) and were initially divided into groups of activators and repressors. Accumulating data suggest that there is no specific role for each individual E2F member. Instead, each E2F can exert a … E2F is a group of genes that encodes a family of transcription factors (TF) in higher eukaryotes. Three of them are activators: E2F1, 2 and E2F3a. Six others act as suppressors: E2F3b, E2F4-8. All of them are involved in the cell cycle regulation and synthesis of DNA in mammalian cells. E2Fs as TFs bind to the … See more Homo sapiens E2F1 mRNA or E2F1 protein sequences from NCBI protein and nucleotide database. See more X-ray crystallographic analysis has shown that the E2F family of transcription factors has a fold similar to the winged-helix DNA-binding motif See more The Rb tumor suppressor protein (pRb) binds to the E2F1 transcription factor preventing it from interacting with the cell's transcription … See more • Transcription factor DP • Type 3c (Pancreatogenic) Diabetes See more • E2F+Transcription+Factors at the U.S. National Library of Medicine Medical Subject Headings (MeSH) • Drosophila E2F transcription factor - The Interactive Fly See more E2F family members play a major role during the G1/S transition in mammalian and plant cell cycle (see KEGG cell cycle pathway). DNA microarray analysis reveals unique sets of target promoters among E2F family members suggesting that each protein has a … See more • Cell cycle: CCNA1,2, CCND1,2, CDK2, MYB, E2F1,2,3, TFDP1, CDC25A • Negative regulators: E2F7, RB1, TP107, TP21 See more how much is my meteorite worth