Cisplatin cyp3a4
WebOct 11, 2024 · Treatment outcomes between FOLFIRINOX (5-fluorouracil, leucovorin, irinotecan, and oxaliplatin) and GNP (gemcitabine with albumin-bound paclitaxel) as first-line chemotherapy regimens for ... WebThe aim of this study was to examine chemotherapeutic drug binding to CYP3A4 and the interactions therein. We have used Schrödinger suite 2014, to perform molecular docking …
Cisplatin cyp3a4
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WebApr 3, 2024 · Fosaprepitant, a prodrug of aprepitant, is a weak inhibitor of CYP3A4, and aprepitant is a substrate, inhibitor, and inducer of CYP3A4. • Use of fosaprepitant with other drugs that are CYP3A4 substrates, may result in increased plasma concentration of the concomitant drug. WebCisplatin is a platinum-based agent whose nephrotoxicity is thought related to the chloride in the cis position. Cisplatin gains entry into tubular cells via uptake by the OCT-2 …
WebJun 30, 2010 · A Clinical Trial Testing The Efficacy Of Crizotinib Versus Standard Chemotherapy Pemetrexed Plus Cisplatin Or Carboplatin In Patients With ALK Positive Non Squamous Cancer Of The Lung (PROFILE 1014) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. WebAgents that are CYP3A4 substrates include etoposide, vinca alkaloids (vincristine, vinblastine, and vinorelbine), irinotecan, and ifosfamide. Cyclophosphamide- In a small pilot study of patients receiving cyclophosphamide plus thiotepa and carboplatin, aprepitant inhibited cyclophosphamide autoinduction by inhibiting CYP enzyme induction.
WebLiều khuyến cáo của docetaxel là 75mg/m 2 truyền tĩnh mạch trong 1 giờ, theo sau là cisplatin 75mg/m2, ... Cần tránh dùng đồng thời docetaxel với các thuốc ức chế CYP3A4 mạnh (ví dụ như ketoconazole, itraconazole. clarithromycin, indinavir, nefazodone, nelfinavỉ, ritonavir, saquinavir, telithoromycin ... WebCisplatin is also sometimes used to treat head and neck cancer (including cancer of the mouth, lip, cheek, tongue, palate, throat, tonsils, and sinuses), lung cancer, cancer of the …
WebCobicistat is a CYP3A4 inhibitor; contraindicated with CYP3A4 substrates for which elevated plasma concentrations are associated with serious and/or life-threatening events. enoxaparin cyclophosphamide increases effects …
WebChemotherapeutic agents that are substrates for CYP3A4 Netupitant is a moderate inhibitor of CYP3A4 and can increase the exposure of chemotherapeutic agents that are substrates for CYP3A4 e.g. docetaxel (see section 4.5). Therefore, patients should be monitored for increased toxicity of chemotherapeutic agents that are substrates for CYP3A4, sainsbury stationeryWeb【基本情况】 魏玉辉 , 1976 年 1 月生 , 主任药师 / 副教授 , 兰州大学第一医院药剂科主任 , 兰州大学第一临床医学院临床药学教研室主任 , 内科学学术型 博士研究生导师、 药学专业型和临床医学学术型 硕士研究生导师。 甘肃省领军人才 。 【学习经历】 1995.9—1999.6 兰州大学 ( 兰州医学院 ... thiensville trick or treatWebZytostatika: Cisplatin, Carboplatin, Oxaliplatin, Satraplatin Platinanaloga verursachen ebenfalls Querver-netzungen der DNA durch kovalente Bindung des Platinatoms an zwei Nukleinbasen. Die DNA kann sich während der Zellteilung nicht korrekt verdoppeln. Die Wirkung beruht also auf einer Hemmung der DNA-Replikation. thiensville vet clinicWeb5.1 Clinically Significant CYP3A4 Drug Interactions Aprepitant is a substrate, weak-to-moderate (dose-dependent) inhibitor, and an inducer of CYP3A4. • Use of CINVANTI … thiensville votingWebDec 1, 2024 · Metoclopramide is a benzamide prokinetic antiemetic agent. It causes central and peripheral dopamine D2 antagonism at low doses, and weak 5-HT 3 blockade at the … sainsbury st ann gloucesterWeb379-NSCLC locally advanced definitive ciSplatin and etoposide chemoradiation eviQ Home Medical oncology Respiratory Non small cell lung cancer Non small cell lung cancer locally advanced definitive ciSplatin and etoposide chemoradiation ID: 379 v.6 Endorsed Essential Medicine List Check for clinical trials in this patient group. sainsbury staplehurst opening timeshttp://vcl-dc2-98-33.hpc.ncsu.edu/detail.go?type=chem&acc=D002945&view=ixn&geneAcc=1576 sainsbury st annes on sea