Cisplatin and kidney

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August undefined, 2024

WebMar 29, 2024 · Administration of the chemotherapeutic agent cisplatin leads to acute kidney injury (AKI). Cisplatin-induced AKI (CIAKI) has a complex pathophysiological map, which has been linked to cellular uptake and efflux, apoptosis, vascular injury, oxidative and endoplasmic reticulum stress, and inflammation … WebMar 13, 2024 · Background. Cisplatin (cis-diamminedichloroplatinum II, CDDP) is one of the most effective chemotherapeutic agents. However, its clinical use is limited due to the severe side effects, including nephrotoxicity and acute kidney injury (AKI) which develop due to renal accumulation and biotransformation of CDDP.

Pathophysiology of Cisplatin-Induced Acute Kidney Injury

WebMitofusin2 ameliorated ER stress and mitochondrial ROS through maintaining mitochondria-associated ER membrane integrity in cisplatin-induced acute kidney injury Mitofusin2 ameliorated ER stress and mitochondrial ROS through maintaining mitochondria-associated ER membrane integrity in cisplatin-induced acute kidney injury WebRenal injury induced by cisplatin primarily occurs in proximal tubules, 1 where the tubular injury causes a decrease in the glomerular filtration rate. 2 Because of this decrease in … the people\u0027s yoga classes

Exploring the Metabolic Differences between Cisplatin- and UV …

WebCisplatin (CP)-induced nephrotoxicity is widely accepted as a model for acute kidney injury (AKI). Although cisplatin-induced chronic kidney disease (CKD) in rodent has been reported, the role of phosphate in the cisplatin-induced CKD progression is not described. WebAug 6, 2014 · Cisplatin and other platinum derivatives are the most widely used chemotherapeutic agents to treat solid tumors including ovarian, head and neck, and … WebCisplatin has been a mainstay of cancer chemotherapy since the 1970s. Despite its broad anticancer potential, its clinical use has regularly been constrained by kidney … the people\u0027s world

Cisplatin dosing, indications, interactions, adverse effects ... - Medscape

WebCisplatin is mainly excreted through the kidneys. It becomes concentrated during excretion, and the concentration in renal tubular epithelial cells is much higher than that in the blood. In the... WebOct 13, 2024 · Cisplatin is nephrotoxin that can cause both acute kidney injury and chronic kidney disease. Accumulation of cisplatin in renal tubular cells induces various … siberian ginseng with ginkgo biloba benefitsWebMar 23, 2024 · Although optimization of dosing and inclusion of cisplatin as part of combination therapy has reduced the incidence of cisplatin-induced acute kidney injury (AKI), nephrotoxicity remains the dose-limiting side effect and is also associated with the risk of future chronic kidney disease (CKD) ( 2 ). the people\\u0027s yoga

"WebRenal stem cell recovery systems, which can limit cisplatin-induced acute kidney injuries, appear to be at least partly dependent on TLR2 activation as well . Some studies have … " - Cisplatin and kidney

Cisplatin and kidney

The use of cisplatin in patients after kidney... : Medicine

WebFeb 16, 2016 · In cisplatin-based CCRT schedules, acute nephrotoxicity is commonly graded by an increase of serum creatinine levels, according to the Common Terminology Criteria for Adverse Events (CTCAE). Using these criteria nephrotoxicity ≥grade 3 occurs in only 4%–9% of patients [ 7, 10, 11 ]. WebCisplatin is a potent antineoplastic agent derived from platinum and commonly used in the treatment of head and ... both water restrictions and sodium supplementation may be appropriate when differentiating between diagnoses of renal salt wasting syndrome and syndrome of inappropriate antidiuretic hormone secretion. Fed Pract. 2024 December;38 ...

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WebCisplatin is a potent antineoplastic agent derived from platinum and commonly used in the treatment of head and ... both water restrictions and sodium supplementation may be … WebJun 18, 2024 · Typical adverse reactions associated with cisplatin include kidney damage, high emetogenic potential, peripheral neuropathy, ototoxicity, and …

WebMar 23, 2024 · Here, we postulated that systemically delivered rapamycin perfluorocarbon nanoparticles (PFC NP) could reach the injured kidneys at sufficient and sustained concentrations to mitigate cisplatin-induced acute kidney injury … WebFeb 16, 2024 · Cisplatin can affect your nervous system, increase your risk of bleeding or infection, or harm your kidneys. Call your doctor if you have a fever, mouth sores, cough, …

WebApr 14, 2024 · Among the changes potentially relevant are the differences in the content of pyridoxine and kynurenine between the two types of ABs, i.e., cisplatin-treated vs. UV light exposed-cells, both in ABs content ( Table 1 and Figure S1) and in the extracellular fluid ( Table 1 and Figure S2 ). WebJul 22, 2024 · Cisplatin is a potent and valuable chemotherapy agent used to treat a broad spectrum of malignancies. Renal tubular dysfunction and a cumulative impairment in …

WebDec 12, 2024 · Cisplatin is mainly excreted through the kidneys and can induce nephrotoxicity through proximal tubular injury, by promoting oxidative stress via reactive oxygen species (ROS), inflammation, apoptosis, autophagy and vascular injury in …

WebAug 6, 2014 · Cisplatin and other platinum derivatives are the most widely used chemotherapeutic agents to treat solid tumors including ovarian, head and neck, and testicular germ cell tumors. A known complication of cisplatin administration is acute kidney injury (AKI). siberiangreen.comWebFeb 15, 2024 · Traditional chemotherapeutic drugs, such as cisplatin and doxorubicin, are commonly used to treat various cancers, including lung, bladder, and ovarian cancer 1, 2, 3, 4. However, severe side... the people under the old regime cartoonWebApr 14, 2024 · Among the extracellular vesicles, apoptotic bodies (ABs) are only formed during the apoptosis and perform a relevant role in the pathogenesis of different diseases. Recently, it has been demonstrated that ABs from human renal proximal tubular HK-2 … siberian ginseng thyroidWebApr 25, 2014 · Cisplatin and other platinum derivatives are the most widely used chemotherapeutic agents to treat solid tumors including ovarian, head and neck, and … siberian goshawk for saleWebCisplatin is one of the most widely used and most potent chemotherapy drugs. However, side effects in normal tissues and organs, notably nephrotoxicity in the kidneys, limit the … siberian green sea buckthorn oilWebJan 1, 2024 · Cisplatin treatment induces premature senescence in renal tubular cells in vitro and in vivo To evaluate whether cisplatin can induce senescence in renal tubular cells in vitro, NRK cells were incubated with cisplatin (20 μg/ml) for 6 h, and then incubated in complete medium for 24, 48, and 72 h. the people\u0027s yoga portlandWebNov 12, 2024 · Nephrotoxicity: cisplatin injection can cause severe renal toxicity, including acute renal failure. Severe renal toxicities are dose-related and cumulative. Consider dose reductions or alternative treatments in patients with renal impairment.Peripheral Neuropathy: cisplatin injection can cause dose-related peripheral neuropathy. siberian ginseng creatinine