Camptothecin biosynthesis
WebMar 31, 2015 · Camptothecin (CPT) is a kind of modified monoterpene indole alkaloid firstly identified from woody plant Camptotheca acuminata, and its semisynthetic CPT analogs irinothecan and topothecan are … Like all other monoterpenoid indole-alkaloids, biosynthesis of camptothecin requires production of the strictosidine. Strictosidine is synthesized through condensation reaction between tryptamine from shikimate pathway and secologanin from either mevalonate (MVA) pathway or non-mevalonate pathway (MEP). Strictosidine then undergoes intermolecular cyclization to pro…
Camptothecin biosynthesis
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WebOct 17, 2024 · Topoisomerase inhibitors have been in use clinically for the treatment of several diseases for decades. Although those enzymes are significant molecular targets in antibacterial and anticancer chemotherapy very little is known about the possibilities to target fungal topoisomerase II (topo II). Raising concern for the fungal infections, lack of … WebDec 2, 2024 · Camptothecin (CPT), a natural alkaloid isolated from Camptotheca acuminata Decne, is found to show potential insecticidal activities with unique action mechanisms by targeting at DNA …
WebCamptothecin is a monoterpene indole alkaloid (MIA) used to produce semisynthetic antitumor drugs. We investigated camptothecin synthesis in Camptotheca acuminata by … WebJul 18, 2016 · Camptothecin is a monoterpene indole alkaloid (MIA) used to produce semisynthetic antitumor drugs. We investigated camptothecin synthesis in Camptotheca acuminata by combining transcriptome and expression data with reverse genetics, biochemistry, and metabolite profiling.
WebDec 4, 2024 · Camptothecin (CPT), a monoterpene indole alkaloid (MIA), is the starting material for the synthesis of topotecan and irinotecan which are well known and clinically plant approved antitumor drugs. Here, we investigated the latest progress in the biosynthesis of MIA in... The biogenesis of camptothecin in C. acuminata is of particular interest because it is considered to be a major source of this anti-tumor alkaloid. Analysis of genes from available C. acuminata transcriptome data has already enabled successful identification of some genes for camptothecin biosynthesis11,31. … See more The previously published C. acuminata genome assembly (Cac genome assembly v2.4) was created with the ALLPATHS-LG assembler using Illumina short-read technology, producing an assembly of 1,394 scaffolds … See more Repetitive sequences were identified using a combination of ab initio and homology-based approaches. In total, 37.55% of the assembled … See more We clustered the annotated genes into gene families for C. acuminata and seven other plant species. A total of 23,047 C. acuminata genes (82.49%) clustered into 13,188 gene families, which included 7,434 (56.37%) gene … See more
WebCancer has taken a toll of 10 million deaths in 2024, almost one in six deaths. Thus, it is a need of time to supply CPT to the pharma industries. Alternative approaches, such as biotechnological tools than the conventional plant propagation methods for the biosynthesis of CPT and its derivative 9‑methoxy-camptothecin (MCPT), are highly ...
WebApr 3, 2024 · Camptothecin (CPT) is a widely known monoterpene indole alkaloid with excellent anticancer activity. CPT has been isolated from different plant species. CPT- producing weedy plant O. pumila has brought about widespread attention, and the whole genome of O. pumila has been sequenced [ 29 ]. crosswinds geneva on the lakeWebFeb 1, 2024 · The plant derived camptothecin (CPT) is a pentacyclic pyrroloquinoline alkaloid with unique antitumor activity. Successive discoveries of new CPT-producing plants occurred in recent years due to... crosswinds fort walton beachWebApr 12, 2024 · Flavonoids encompass a heterogeneous group of secondary metabolites with exceptional health benefits. Chrysin, a natural dihydroxyflavone, possesses numerous bioactive properties, such as anticancer, antioxidative, antidiabetic, anti-inflammatory, etc. However, using traditional sources of chrysin involves extracting honey from plants, … build a wooden sailboatWebMar 24, 2024 · We used a combined omics approach to analyze the elicitation effects of MeJa, AgNO3, and PEG on camptothecin (CPT) biosynthesis in Camptotheca … build a wooden razor standWebApr 22, 2024 · VDOMDHTMLOCTYPE html> Identification of WRKY transcription factors involved in regulating the biosynthesis of the anti-cancer drug camptothecin in Ophiorrhiza pumila Horticulture Research Oxford Academic Abstract. Camptothecin is a chemotherapeutic drug widely used to treat various cancers. build a wooden seawallWebDec 17, 2024 · Camptothecin (CPT), a monoterpene indole alkaloid (MIA), was initially isolated and identified from Camptotheca acuminata. Later investigation showed that CPT and its derivatives could inhibit DNA topoisomerase I activity, which led to it being used as a promising anti-tumor drug for treating cancer diseases in clinical therapy [ 1, 2, 3 ]. crosswinds georgia at twin lakesWebApr 22, 2024 · Camptothecin (CPT) is a chemotherapeutic drug widely used to treat various cancers. Ophiorrhiza pumila is an ideal model for a camptothecin-producing plant with various advantages for studying... build a wooden side table furniture